Does F3 change?
Discussion
Not that I'm aware of - enemies respawn after a certain amount of time (normal enemies like raiders, etc., not the Behemoths), items in safes, lockers, etc. do not. I think you're just noticing things you haven't noticed before, or taking different routes to locations, as the Wasteland game area is so vast. The DLC adds a few map marker locations and changes some bits (e.g. the Zeta spaceship), but that's all I can think of.
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